TREXIMET® for Migraines Headaches - U.S. HEALTH RESOURCES AND SERVICES - 2024.04.23

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✓ TREXIMET® for Migraines Headaches

GlaxoSmithKline offers several patient assistance programs to help eligible individuals without prescription medicine coverage obtain free GlaxoSmithKline medicines through the mail. Learn more »

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Important Safety Information about TREXIMET

TREXIMET may increase the risk of heart attack, stroke, serious stomach and intestinal problems such as bleeding and ulcers, and serious rash that may be fatal and occur without warning. Risk of stomach and intestinal problems increases in the elderly.

Do not take TREXIMET if you have a history of heart or liver disease, stroke, TIAs, problems with blood circulation, uncontrolled blood pressure, or allergic reaction to aspirin, NSAIDs, or sumatriptan (Imitrex®); or right before or after heart surgery called coronary artery bypass graft (CABG).

Talk to your doctor before taking TREXIMET if you have risk factors for heart disease like high blood pressure, high cholesterol, smoking, obesity, diabetes, family history of heart disease, are a post-menopausal female, or male over age 40.

Talk to your doctor before taking TREXIMET if you have stomach ulcers or bleeding; chest pain, shortness of breath, irregular heartbeats; kidney problems; are pregnant, nursing, or thinking about becoming pregnant; or taking medications, especially pain relievers or antidepressants. Serotonin syndrome, a life-threatening problem, may occur with TREXIMET, especially if used with antidepressants called SSRIs or SNRIs. Do not take TREXIMET if you have taken an MAOI antidepressant within the last 2 weeks. TREXIMET should only be used exactly as prescribed, at the lowest dose and for the shortest time possible.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.
What Foods Trigger Headaches and Migraines?

Some of the most common foods, beverages, and additives associated with headaches include:
- Aged cheese and other tyramine-containing foods: Tyramine is a substance found naturally in some foods. It is formed from the breakdown of protein as foods age. Generally, the longer a high-protein food ages, the greater the tyramine content. The amount of tyramine in cheeses differs greatly due to the variations in processing, fermenting, aging, degradation, or even bacterial contamination. For people who take monoamine oxidase (MAO) inhibitor medications to treat their headaches, it is especially important to avoid all foods containing tyramine, including aged cheeses, red wine, alcoholic beverages, and some processed meats, as these foods can trigger severe high blood pressure.
- Alcohol: Blood flow to your brain increases when you drink alcohol. Some scientists blame the headache on impurities in alcohol or by-products produced as your body metabolizes alcohol. Red wine, beer, whiskey, and champagne are the most commonly identified headache triggers.
- Food additives: Preservatives (or additives) contained in certain foods can trigger headaches. The additives, such as nitrates, dilate blood vessels, causing headaches in some people.
- Cold foods: Cold foods can cause headaches in some people. It’s more likely to occur if you are over-heated from exercise or hot temperatures. Pain, which is felt in the forehead, peaks 25 to 60 seconds and lasts from several seconds to one or two minutes. More than 90% of migraine sufferers report sensitivity to ice cream and cold substances.
Do Other Foods Trigger Headaches and Migraines?

These foods have been identified as headache and migraine triggers by some sufferers.
- Peanuts, peanut butter, other nuts and seeds
- Pizza
- Potato chip products
- Chicken livers and other organ meats
- Smoked or dried fish
- Sourdough bread, fresh baked yeast goods (donuts, cakes, homemade breads, and rolls)
- Bread, crackers, and desserts containing cheese
- Certain fresh fruits including ripe bananas, citrus fruits, papaya, red plums, raspberries, kiwi, pineapple
- Dried fruits (figs, raisins, dates)
- Soups made from meat extracts or bouillon (not homemade broth)
- Cultured dairy products, sour cream, buttermilk, yogurt
- Caffeine found in chocolate and cocoa; beverages such as coffee, tea and colas; also found in certain medications
- Aspartame and other artificial sweeteners

TREXIMET® for Migraines Headaches

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✓ TREXIMET® for Migraines Headaches

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